RESEARCH STUDIES

The next generation of AG1 is clinically backed.

Our innovation is driven by our ongoing investments in research and clinical discovery. We ensure the benefits of our products are thoroughly researched and any claims are substantiated by multiple bodies of research on ingredients and the finished formula. The impact of AG1 Next Gen is not just experienced, it's measurable.*1-4

One product, four gold-standard clinical trials.

AG1 Next Gen has been put to the test in multiple gold-standard clinical trials, consistently showing its efficacy in closing nutrient gaps and supporting gut health across diverse populations and study designs.*1-4

Our research findings

NUTRITIONAL GAPS

AG1 Next Gen is clinically shown to fill common nutrient gaps even in healthy eaters.¹⁻⁴

WHY THIS MATTERS

In four randomized, placebo-controlled trials—meeting strict and widely accepted standards for clinical research—AG1 Next Gen demonstrated a statistically significant and positive impact on closing common nutrient gaps. These studies included participants with diverse diets, backgrounds, ages, and activity levels.¹⁻⁴

NUTRITIONAL GAPS

AG1 Next Gen improves key nutrient levels within 3 months.¹

7 in 10
subjects drinking AG1 Next Gen had an increase in RBC folate.1

WHY THIS MATTERS

Adequate micronutrients are needed to support the body in the production of energy, building proteins, and metabolizing food. They act as co-factors and individual building blocks. Maintaining consistent intake is key for overall health.*

33%
increase in Vitamin C levels1

WHY THIS MATTERS

Vitamin C supports the body's ability to combat oxidative stress and support immune defenses. It is a super antioxidant that plays a fundamental role in various physical and cellular processes.*

GUT HEALTH

AG1 Next Gen is clinically shown to enrich the gut microbiome.¹⁻³

Over 10x
Average increase in healthy bacteria in the gut1-3

WHY THIS MATTERS

Beneficial bacteria—such as the probiotic strains in AG1 Next Gen—are important for maintaining a healthy microbiome and play a key role in supporting overall gut health.*

BIOAVILABILITY

Key nutrients in AG1 Next Gen were shown to be quickly and easily absorbed into the body.⁴

Folate levels were significantly increased within 30 minutes of drinking AG1 Next Gen.4

WHY THIS MATTERS

AG1 Next Gen delivers key nutrients like folate, vitamin C, and zinc—in bioavailable forms the body can easily and readily utilize, maximizing their potential benefits.*

1 Triple-blind, randomized, placebo-controlled parallel-designed clinical trial evaluating nutrient biomarkers and microbiome shifts in 105 healthy adults ages 20-59 over the course of 12 weeks.
2 Double-blind, randomized, placebo-controlled 2-week crossover clinical trial assessing nutrient gaps and microbiome shifts in 20 active adults ages 19-37.
3 Double-blind, randomized, placebo-controlled 2-week crossover clinical trial assessing nutrient gaps and microbiome assessments of 24 healthy adults with occasional GI distress ages 26-59.
4 Double-blind, randomized, placebo-controlled crossover clinical trial assessing nutrient gaps and bioavailability in 16 healthy adults ages 18-42 over the course of 8 hours.

What powers our research

There are many ways to study how nutrition impacts the body. In our clinical research, we use advanced tools and technologies—alongside our academic and clinical partners—to explore the connection between nutrient intake and microbiome composition.

OUR TEAM

Our research team

Our in-house team of clinicians and scientists bring diverse expertise across nutrition, metabolism, microbiome, and related fields. We also collaborate with independent experts, academic institutions, and clinical partners to advance research and expand our understanding with cutting-edge technology.

Dr. Ralph Esposito

ND, LAc — Functional Medicine

Dr. Lara Nyman

PhD — Molecular Physiology

Dr. Ren-hau La

PhD, TCMD — Traditional Chinese Medicine

Dr. Sonia Malani

ND, FABNO — Integrative Medicine

Dr. Jeremy Townsend

PhD — Exercise Physiology

Dr. Trevor Kirby

PhD — Molecular Medicine

Dr. Philip Sapp

PhD — Nutritional Science

Dr. Caitlyn Edwards

PhD, RD — Nutritional Science

Olivia Pelaez

MS, IFNCP — Functional Nutrition

Alexandra Wood

MS, Nutrition Science

FAQ

What is AG1 Vitamin D3+K2 product?
Vitamin D3+K2 complements AG1 with a single-drop formula in a bioavailable oil form. The product is formulated separately from AG1 to provide optimal quality and bioavailability.
AG1 Omega 3 complements AG1 with high-quality EPA and DHA in a bioavailable oil form. Each serving provides over 2000mg, sourced from wild-caught small fish that are molecularly distilled for purity and quality. The product is formulated separately from AG1 to provide optimal bioavailability.
Since 2010, we’ve earned the trust of millions worldwide through our uncompromising commitment to quality, efficacy, and safety. This includes: Multiple gold-standard clinical trials that consistently show AG1 Next Gen helps fill nutrient gaps across a range of lifestyles and diets (1-4). NSF Certified for Sport®, a rigorous third-party certification ensuring AG1 is free from over 280 banned substances, including stimulants, narcotics, diuretics, and masking agents.
AG1 ingredients are sourced from quality partners for absorption, potency, and nutrient density. You can read more about the 75+ ingredients in AG1 here.
We rigorously test AG1 for hundreds of contaminants. This includes over 500 pesticides and herbicides. Through NSF Certified for Sport® , an independent third-party program that certifies dietary supplements are free from substances banned by major sporting organizations, we also test for over 280 banned substances, including stimulants, narcotics, diuretics, and masking agents.
AG1 isn’t certified organic, but we go beyond by using non-GMO ingredients and testing for over 500 pesticides and herbicides, including glyphosate. You can read more about our quality standards here.
AG1 contains a blend of 5 clinically-studied probiotics , which we source from highly reputable sources. Our probiotics are non-dairy, made through fermentation, and not of animal or soil origin.
Since AG1 contains live probiotics and many whole-food sourced ingredients, the pouch should be refrigerated after opening.